Research peptides

CJC-1295 Overdose: What to Do

CJC-1295 overdose: emergency signs, Poison Control, and what to tell a clinician. No published human overdose case exists - here is what is actually known.

Written bySebastian Hunter, Founder and EditorI'm a 42-year-old senior advisor and distance runner who came to peptides as a sceptic. I'm not a doctor: I read the research, run my own experiment and keep honest notes. Read full bio

Published September 27, 2026

The short version

There is no published human case report of a CJC-1295 overdose. If you or someone else has taken an unknown or excessive amount of anything sold as CJC-1295, call Poison Control at 1-800-222-1222 (verify that number yourself). Get emergency care for severe symptoms. The only published human dosing data comes from a small trial using 30 or 60 mcg/kg, which reported no serious adverse reactions. That trial did not test higher amounts and is not a safety ceiling.

No published human overdose case report exists for CJC-1295, in either form.
Call 911 for severe or rapidly worsening symptoms; call Poison Control at 1-800-222-1222 for guidance on a suspected overdose that is not an emergency.
The one published human trial tested 30-60 mcg/kg with no serious adverse reactions reported. It never tested an overdose amount.
An unlabelled research vial carries no verified concentration, so "how much was taken" is often unknown. Tell a clinician that.

If you or someone else has taken an unknown or excessive amount of anything sold as CJC-1295, act first using the box below. The evidence context can wait.

US legal status - Research use only

CJC-1295 has no FDA-approved product, in either form, and no FDA-reviewed dose, label or overdose guidance.

AU legal status - Not on the ARTG

Not on the Australian Register of Therapeutic Goods, so the TGA has not assessed it for safety, quality or effectiveness. Goods that are not on the ARTG cannot lawfully be supplied or advertised in Australia except through a specific pathway - the Special Access Scheme, an Authorised Prescriber, a clinical trial, or personal importation.

Regulators reach their own conclusions on their own timelines. Where these two disagree, the difference is the point - not an error.

What to tell a clinician or Poison Control

The exact product name and any label or lot information on the vial or packaging.
The amount you believe was taken, in the units printed on the vial (mg or mcg), and how it was reconstituted if you know. If the actual amount is unknown, say so. That is common with an unlabelled research vial and is itself useful information.
The route (injection) and roughly when it happened.
Anything else taken around the same time, including alcohol or other research compounds.
The specific symptoms, and when each one started.

There is no published human overdose case report

I searched for a published case report, toxicity study or case series describing a CJC-1295 overdose, in either the with-DAC or without-DAC form, and found none. That does not mean it is safe. It means no such case has been documented in the peer-reviewed literature I can cite here. Do not read the absence of a published case as evidence that a large amount is harmless.

What the one published human trial actually tested

The only published human dosing data for CJC-1295 comes from a randomised, placebo-controlled trial in healthy adults aged 21-61, using the long-acting with-DAC form Teichman 2006 - Teichman SL, Neale A, Lawrence B et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91(3):799-805., in the references below:

Part	Dose	Schedule
Single ascending dose	Doses including 30 and 60 mcg/kg	One subcutaneous injection, followed 28 days
Repeat dose	30 or 60 mcg/kg	2-3 subcutaneous injections, weekly or biweekly, followed 49 days

The paper describes these doses as “safe and relatively well tolerated,” with no serious adverse reactions reported at either level. That is the highest dose tested in any published human study of CJC-1295. The trial did not push further to find an upper limit, so 60 mcg/kg is where the published human evidence stops, not a demonstrated ceiling of safety.

Limited human data

Small or uncontrolled human studies. Too little to settle the question either way. One small placebo-controlled human trial has published dosing and tolerability data for the with-DAC form, at 30-60 mcg/kg. No published human trial has tested a higher amount, and no published case report describes an overdose in either form.

The without-DAC form (sold as mod GRF 1-29) has no published human dosing or safety study of any kind. There is even less basis for any dose-related statement about it.

Why “how much did you take” is often unknowable here

An unapproved research vial has no FDA-reviewed manufacturing standard, no verified concentration, and no guarantee it contains only CJC-1295 at the labelled strength. A person who thinks they took “too much” often cannot know what amount of what substance they actually received.

Say that to a clinician or Poison Control rather than guessing a number. It is more useful than an invented figure, and it does not change the urgency of calling if symptoms are severe.

Common questions

What should I do if I think someone has overdosed on CJC-1295?

Call 911 (in the US) for any severe or rapidly worsening symptom: difficulty breathing, facial or throat swelling, chest pain, fainting or severe confusion. For a suspected overdose that is not causing those signs, call Poison Control at 1-800-222-1222, which is free, confidential and available around the clock. Bring or photograph the vial or packaging so a clinician can see what was actually labelled.

Is there a known lethal or toxic dose of CJC-1295?

No. I could not locate any published human case report of a CJC-1295 overdose, toxic dose or fatality, in either the with-DAC or without-DAC form. No published case does not prove safety at high doses. It means no such dose has been studied or documented in the literature I can cite.

What did the one published human trial find about high doses?

A published trial in healthy adults tested CJC-1295 with-DAC at 30 or 60 mcg/kg, as single ascending doses and as 2-3 repeat doses. It reported no serious adverse reactions at either dose level. That is the top of what a published human trial has studied. It did not test an overdose amount, and nothing above 60 mcg/kg has been reported in the human literature I can verify.

What symptoms would suggest a problem after taking CJC-1295?

No published overdose case exists, so there is no verified symptom list specific to CJC-1295 overdose. General reasons to seek care after any injection are facial, lip, tongue or throat swelling, difficulty breathing, chest pain, and fainting or severe dizziness. Others are a severe or spreading injection-site reaction, or any symptom that feels dangerous or is getting rapidly worse. Treat these as reasons to call 911, not as a checklist to self-diagnose against.

What should I tell a clinician or Poison Control?

Give the exact product name and any lot or batch information on the vial or packaging. Say how much you believe was taken, in the units on the vial (mg, mcg, or "units" on a syringe), and how it was reconstituted if you know. Add the time it was taken, the route (injection), any other substances taken around the same time, including alcohol, and the specific symptoms and when they started. An unlabelled research vial has no verified concentration, so say so if the actual amount is not known. That is useful information too.

Is Poison Control only for children or accidental exposures?

No. Poison Control (1-800-222-1222 in the US) takes calls about any suspected poisoning or overdose, at any age, including intentional or research-chemical exposures. The call is free and confidential. It is a reasonable first call for a suspected CJC-1295 overdose that is not causing severe symptoms needing 911.

References (2 sources)

Bibliographic detail is fetched from PubMed, not written by me - so a citation here cannot drift from the paper it names. Study design comes from PubMed's own tags rather than my judgement.