Bioregulators
Short peptides developed at the St Petersburg Institute of Bioregulation and Gerontology, each named for the organ it is said to target. Most of the research comes from that one group.
What bioregulators are and how strong the evidence is: peptide bioregulators explained.
aka Epithalon · Epithalamin · AEDG peptide
Sold for longevity and anti-aging on the basis of telomere research.
Animal / lab onlyResearch use only
aka EDR peptide · Glu-Asp-Arg
Sold for cognition, focus and healthy aging.
Limited human dataResearch use only
aka AED peptide · Ala-Glu-Asp · T-31
Marketed for cartilage and joint support, sold as a "cartilage bioregulator" for age-related joint wear.
Animal / lab onlyResearch use only
aka KEDG peptide · Lys-Glu-Asp-Gly
Marketed for testosterone and reproductive-system support, sold as a "testes bioregulator."
Animal / lab onlyResearch use only
aka KE peptide · Lys-Glu dipeptide
Marketed as a thymus and immune-system bioregulator, sold for immune support and healthy ageing.
Animal / lab onlyResearch use only
aka KED · KED peptide · Lys-Glu-Asp
Marketed as a vascular-tissue bioregulator for cardiovascular and blood-vessel aging; more recent papers from the same research group also study it as a candidate for age-related cognitive decline.
Limited human dataResearch use only
aka AEDR · AEDR peptide · Ala-Glu-Asp-Arg
Marketed as a heart-tissue bioregulator for cardiovascular aging, from the Khavinson organ-specific peptide programme.
Animal / lab onlyResearch use only
aka KEDP · KEDP peptide · Lys-Glu-Asp-Pro
Marketed as a prostate-tissue bioregulator for age-related prostate change, from the Khavinson organ-specific peptide programme.
Animal / lab onlyResearch use only
aka AEDP · AEDP peptide · Ala-Glu-Asp-Pro
Marketed as a brain-cortex bioregulator for cognitive aging, from the Khavinson organ-specific peptide programme. Its sequence was derived by amino-acid analysis of the natural brain-cortex extract preparation Cortexin.
Animal / lab onlyResearch use only
aka AEDL peptide · Bronchogen tetrapeptide
Sold for bronchial and lung support, marketed within the Khavinson peptide-bioregulator line for respiratory and healthy-aging use.
Animal / lab onlyResearch use only
aka Chonluten tripeptide
Marketed for bronchial and respiratory support alongside Bronchogen, within the Khavinson peptide-bioregulator line.
Animal / lab onlyResearch use only
aka KEDA peptide · Lys-Glu-Asp-Ala
Marketed for liver support and healthy aging within the Khavinson peptide-bioregulator line.
Animal / lab onlyResearch use only
aka Ova bioregulator
Marketed for ovarian and reproductive-system support and healthy aging, within the Khavinson peptide-bioregulator line.
No meaningful evidenceResearch use only
aka Immune bioregulator tripeptide
Marketed for immune-system support and healthy aging, within the Khavinson peptide-bioregulator line.
Animal / lab onlyResearch use only
aka Lys-Glu-Asp-Trp-NH2 · KEDW peptide
Marketed for pancreatic and metabolic support and healthy aging, within the Khavinson peptide-bioregulator line.
Limited human dataResearch use only
Side by side
Doses for unapproved compounds are common practice, not trial-established.
| Compound | Main use | Evidence | Usual dose | US status |
|---|---|---|---|---|
| Epitalon | Sold for longevity and anti-aging on the basis of telomere research. | Animal / lab only | 5-10 mg, once nightly, every night, for the length of the cycle | Research use only |
| Pinealon | Sold for cognition, focus and healthy aging. | Limited human data | 1-2 mg, once daily, morning preferred; some protocols run 5 days a week rather than every day | Research use only |
| Cartalax | Marketed for cartilage and joint support, sold as a "cartilage bioregulator" for age-related joint wear. | Animal / lab only | 200 mcg, once daily | Research use only |
| Testagen | Marketed for testosterone and reproductive-system support, sold as a "testes bioregulator." | Animal / lab only | 10-20 mg, once daily by mouth | Research use only |
| Vilon | Marketed as a thymus and immune-system bioregulator, sold for immune support and healthy ageing. | Animal / lab only | 10-20 mg, once daily by mouth | Research use only |
| Vesugen | Marketed as a vascular-tissue bioregulator for cardiovascular and blood-vessel aging; more recent papers from the same research group also study it as a candidate for age-related cognitive decline. | Limited human data | 500-5000 mcg, once daily, subcutaneous, commonly started low and titrated upward over the first 1-3 weeks | Research use only |
| Cardiogen | Marketed as a heart-tissue bioregulator for cardiovascular aging, from the Khavinson organ-specific peptide programme. | Animal / lab only | 200-2000 mcg, once daily, subcutaneous, most commonly cited around 1 mg/day | Research use only |
| Prostamax | Marketed as a prostate-tissue bioregulator for age-related prostate change, from the Khavinson organ-specific peptide programme. | Animal / lab only | 750-2000 mcg, once daily, subcutaneous, often started lower and increased after 1-4 weeks | Research use only |
| Cortagen | Marketed as a brain-cortex bioregulator for cognitive aging, from the Khavinson organ-specific peptide programme. Its sequence was derived by amino-acid analysis of the natural brain-cortex extract preparation Cortexin. | Animal / lab only | 200-10000 mcg, once daily, subcutaneous, ideally in the morning; sources give very different amounts depending on intended use | Research use only |
| Bronchogen | Sold for bronchial and lung support, marketed within the Khavinson peptide-bioregulator line for respiratory and healthy-aging use. | Animal / lab only | 1-2 mg, once daily, consistent time of day | Research use only |
| Chonluten | Marketed for bronchial and respiratory support alongside Bronchogen, within the Khavinson peptide-bioregulator line. | Animal / lab only | No consistent protocol | Research use only |
| Livagen | Marketed for liver support and healthy aging within the Khavinson peptide-bioregulator line. | Animal / lab only | No consistent protocol | Research use only |
| Ovagen | Marketed for ovarian and reproductive-system support and healthy aging, within the Khavinson peptide-bioregulator line. | No meaningful evidence | 10-20 mg, 1-2 capsules (10 mg each), taken once or twice daily before meals | Research use only |
| Crystagen | Marketed for immune-system support and healthy aging, within the Khavinson peptide-bioregulator line. | Animal / lab only | 200-400 mcg, once daily during an initial course; some protocols move to every-other-day dosing for a longer maintenance phase | Research use only |
| Pancragen | Marketed for pancreatic and metabolic support and healthy aging, within the Khavinson peptide-bioregulator line. | Limited human data | 10-20 mg, 1-2 capsules (10 mg each), once or twice daily before meals | Research use only |