Browse by goal
Peptides and Healthy Aging: Joints, Bone and the Evidence
Collagen peptides have randomised human trials for joint comfort and some bone measures, at larger doses and over longer periods than the skin studies used. Beyond that, robust human evidence for slowing aging is missing - the longevity peptides are research-use-only and rest on animal work. For the skin and hair side of aging, see Skin & beauty.
Most discussed here: Collagen peptides
The compounds
Each one leads with how strong its human evidence is, and what that rating is based on.
- Prescription / GLP-1GHRH analogue (first 29 amino acids)
Sermorelin
Marketed to adults for sleep, body composition and aging. Approved use was growth hormone deficiency in children.
- Research peptidesMitochondria-targeted tetrapeptide
SS-31
Investigated for rare genetic mitochondrial disease. Sold online as a longevity and cellular-energy peptide.
- Research peptidesMitochondrial-derived peptide (16 amino acids)
MOTS-c
Sold for metabolic health, fat loss and longevity. Studied in humans as a biomarker of exercise response.
- Research peptidesSynthetic tetrapeptide (Ala-Glu-Asp-Gly)
Epitalon
Sold for longevity and anti-aging on the basis of telomere research.
- Research peptidesSynthetic tripeptide (Glu-Asp-Arg)
Pinealon
Sold for cognition, focus and healthy aging.
The reading
- Collagen & skin
Best Collagen Peptides: Choosing on the Evidence
Studied doses, third-party testing, molecular-weight marketing and cost per studied dose. The criteria that separate a good collagen from a well-advertised one.
Read guide→ - Collagen & skin
Collagen Peptide Benefits: What Human Studies Support
Skin, joints, bone and nails: what collagen trials measured, how large the effects were, and which benefit claims run past the evidence.
Read guide→ - Collagen & skin
Collagen Peptides for Joints: What the Trials Found
Joint comfort and function trials for hydrolyzed collagen and undenatured type II collagen, with the doses, the effect sizes, and who paid for the research.
Read guide→ - Collagen & skin
Collagen Peptides: What the Human Trials Found
Hydrolyzed collagen has real human trials behind it. The effect sizes for skin and joints, the doses used, who funded the studies, and what is still open.
Read guide→ - Research peptides
Epitalon: One Telomere Study, in Cell Lines, Doing All the Work
Epitalon has 142 papers, one tagged clinical trial and no randomised ones. The telomere result everyone cites was in cultured cells, not people.
Read guide→ - Research peptides
MOTS-c: The Human Studies Are About Exercise, Not Injections
Every MOTS-c protocol online gives you milligrams. The human research measures your own MOTS-c rising after exercise. That gap is the whole story of this compound.
Read guide→ - Research peptides
Pinealon: Twenty-Two Papers and No Clinical Trials
Pinealon is a three-amino-acid peptide with a mechanism hypothesis and essentially no human evidence. This is the shortest page on the site, and that is the finding.
Read guide→ - Prescription
Sermorelin: What the Trials Studied, and Who They Studied It In
Approved in 1997 for children with growth hormone deficiency, discontinued in 2008 - and the FDA says not for safety reasons. What the trials actually studied.
Read guide→ - Research peptides
SS-31 (Elamipretide): The Phase 3 Trial Missed Its Endpoints
SS-31 is a real drug in real trials for rare mitochondrial disease, not aging. Its largest controlled trial missed its primary endpoints. Vendors omit that.
Read guide→