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Research peptides

GHRP-2: Benefits, Dosage, Side Effects and Legal Status

GHRP-2: how it works, the common dose, what human studies measured, FDA-flagged side effects and the WADA ban. Approved only in Japan, as a diagnostic test.

The short version

GHRP-2 is a synthetic growth hormone releasing peptide sold as a research chemical, mostly for muscle. Its only approval is in Japan, as a diagnostic test of growth hormone release. FDA has flagged it for safety risks in compounding, and it is banned in sport at all times. Human studies measured growth hormone, appetite and other hormones; none shows it builds muscle.

  • Not FDA-approved for anything; DailyMed has no label for it. Its only approval is in Japan, as a diagnostic test of growth hormone release.
  • FDA lists GHRP-2 in Category 2 of its compounding safety-risk policy, citing reports of serious adverse events.
  • Banned at all times in sport - named explicitly as GHRP-2 (pralmorelin) by WADA.
  • In human studies it increased appetite and raised prolactin, ACTH and cortisol as well as growth hormone.
  • No controlled human trial I verified shows GHRP-2 builds muscle.

GHRP-2 at a glance

What it is
Synthetic hexapeptide, one of the growth hormone releasing peptides (GHRPs)
Main use
Sold to consumers as a growth-hormone-release research chemical for muscle and recovery use, an application never approved anywhere. Historically investigated as a pituitary growth-hormone stimulus and diagnostic agent.
Generic name
pralmorelin
Brand names
GHRP Kaken 100 (approved outside the US only) Label
Also called
Growth Hormone Releasing Peptide-2, KP-102, GPA-748
Molecular formula
C45H55N9O6 (818.0 g/mol) Structure
Evidence
Limited human data
US status
Research use only
Australia
Not on the ARTG
Half-life
About 0.55 hours (roughly 33 minutes) elimination half-life after a single 1 mcg/kg intravenous dose, in one phase I study of 10 children with short stature. No adult half-life after subcutaneous injection was found.
How it is taken
Subcutaneous injection
Common protocol
100-300 mcg, 2 to 3 times daily, on an empty stomach, 5 days a week (5 on, 2 off), for 8 weeks (common practice, not trial-established) Dosage chart

Dosing: what the diagnostic-test studies used.

GHRP-2 (pralmorelin) is a synthetic peptide in the growth hormone releasing peptide (GHRP) family, the same family as GHRP-6. It is sold as a research chemical, mostly for muscle and growth hormone. It is not FDA-approved for anything, FDA has flagged it for safety risks when compounded, and it is banned in sport at all times.

Its human research goes back to the 1990s. Most of it uses GHRP-2 as a one-off test of how much growth hormone the pituitary can release. The rest are small studies of appetite, other hormones, growth in children and critical illness. None measured muscle, strength or body composition in healthy adults.

Limited human data

Small or uncontrolled human studies. Too little to settle the question either way. Human studies are mostly single-dose diagnostic tests of growth hormone release, plus small studies of appetite, other hormones and growth in children and critically ill patients. None I verified tested muscle, strength or body composition. Regulators add an FDA safety-risk listing for compounding and an explicit WADA ban.

How GHRP-2 works

GHRP-2 switches on the growth hormone secretagogue receptor (GHS-R1a), which makes the pituitary release growth hormone. It is the same receptor that ghrelin, the body’s hunger hormone, activates Laferrère 2005 - Laferrère B, Abraham C, Russell CD et al. Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men. J Clin Endocrinol Metab. 2005;90(2):611-4., in the references below.

That overlap explains why GHRP-2 raises appetite, and human studies confirm it. An infusion under the skin increased how much 7 lean healthy men ate at a buffet by 35.9% compared with saline Laferrère 2005 - Laferrère B, Abraham C, Russell CD et al. Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men. J Clin Endocrinol Metab. 2005;90(2):611-4., in the references below. In 19 lean and obese adults, the increase rose with dose Laferrère 2006 - Laferrère B, Hart AB, Bowers CY. Obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intake. Obesity (Silver Spring). 2006;14(6):1056-63., in the references below.

GHRP-2 doesn’t act on growth hormone alone. In 6 healthy young adults it also raised prolactin, ACTH and cortisol. The ACTH and cortisol rise was similar to that from corticotropin-releasing hormone Arvat 1997 - Arvat E, di Vito L, Maccagno B et al. Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man. Comparison with the effects of GHRH, TRH and hCRH. Peptides. 1997;18(6):885-91., in the references below.

GHRP-2 structure

2D chemical structure of GHRP-2, C45H55N9O6
2D structure from PubChem CID 6918245 (NCBI, public domain). Open it in PubChem to zoom or view in 3D.
Molecular formula
C45H55N9O6
Molecular weight
818.0 g/mol
Length
6 amino acids
Sequence
AXAWFK
Modifications
D-Ala1; X2 = D-3-(2-naphthyl)alanine (D-2-Nal); L-Ala3; L-Trp4; D-Phe5; L-Lys6; C-terminal amide.
PubChem CID
6918245

Identity checked against ChEMBL (EMBL-EBI).

GHRP-2 benefits: what the research shows

GHRP-2 has a firmer human record than most peptides sold alongside it. It releases growth hormone reliably enough that Japan approved it as a diagnostic test.

These are encouraging results in specific medical settings. None measured muscle mass, strength or body composition in healthy adults. Whether GHRP-2 builds muscle, the use it is mostly sold for, has not been tested in a controlled trial, and it is not approved anywhere for that use.

GHRP-2 dosage

The common GHRP-2 dose is 100-300 mcg, 2 to 3 times daily, on an empty stomach, 5 days a week (5 on, 2 off). From a 5 mg vial mixed with 2 mL of bacteriostatic water, 200 mcg is 8 units (0.08 mL) on a U-100 insulin syringe.

See the full GHRP-2 dosage chart →

No clinical trial has set a dose. Research-community sources describe 100-300 mcg injected under the skin 2-3 times a day on an empty stomach, 5 days on and 2 off, in 8-week cycles with a 4-week break. It is often mixed with CJC-1295 in the same syringe. That is common practice, not a tested dose. Full sourcing: GHRP-2 dosage.

GHRP-2 side effects

The side effects a regulator has named are the ones in FDA’s Category 2 compounding flag. Human studies add the effects below.

Reported in studies

Rare but serious

Reported by users

A 2026 endocrinology review, written for doctors seeing people who inject growth-hormone peptides including GHRP-2, lists the problems reported across the group Dominikowski 2026 - Dominikowski A, Rękoś Z, Olejarz M et al. The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration. Front Endocrinol (Lausanne). 2026;17:1822475., in the references below:

  • fluid retention
  • muscle and joint aches
  • appetite changes
  • blood-sugar changes
  • raised prolactin and cortisol
  • injection-site reactions

These are reported for the class as a whole, not measured for GHRP-2 alone. For redness, itching or swelling at the injection site, see injection-site reactions.

US legal status - Research use only

Sold for laboratory research use only. Not approved by the FDA for human use, and cannot be lawfully marketed as a supplement or a medicine. Products sold this way are not made to pharmaceutical quality standards, and their contents are not verified by anyone.

AU legal status - Not on the ARTG

Not on the Australian Register of Therapeutic Goods, so the TGA has not assessed it for safety, quality or effectiveness. Goods that are not on the ARTG cannot lawfully be supplied or advertised in Australia except through a specific pathway - the Special Access Scheme, an Authorised Prescriber, a clinical trial, or personal importation.

Regulators reach their own conclusions on their own timelines. Where these two disagree, the difference is the point - not an error.

United States

GHRP-2 is not FDA-approved for anything. On 24 September 2026 I searched DailyMed, the National Library of Medicine’s database of FDA drug labels, and found no labels for it. It is not a dietary supplement or a cosmetic, and it is sold as a research chemical labelled not for human use.

FDA lists “Growth hormone releasing peptide-2 (GHRP-2) (for injectable and nasal routes of administration)” in Category 2 of its interim compounding policy, for substances with potential significant safety risks. The listing applies to 503B outsourcing facilities and was added on 29 September 2023. Unlike some peptides, GHRP-2 has not moved to the table of withdrawn nominations; it remains in the active Category 2 table. The adverse events FDA cites are in the side effects section above.

GHRP-2 is reported to be the only GHRP approved anywhere Popławska 2019 - Popławska M, Błażewicz A. Identification of a novel growth hormone releasing peptide (a glycine analogue of GHRP-2) in a seized injection vial. Drug Test Anal. 2019;11(1):162-167., in the references below. Japan’s drug classification lists pralmorelin hydrochloride as a diagnostic agent for testing endocrine function: a one-off test of growth hormone release, not a treatment. The Japanese validation study used a single 100 microgram intravenous dose Chihara 2007 - Chihara K, Shimatsu A, Hizuka N et al. A simple diagnostic test using GH-releasing peptide-2 in adult GH deficiency. Eur J Endocrinol. 2007;157(1):19-27., in the references below.

Sport: banned at all times

I checked the current Prohibited List on wada-ama.org. Under section S2.2, Peptide Hormones and their Releasing Factors, the GH-releasing peptides named as examples are “alexamorelin, examorelin (hexarelin), GHRP-1, GHRP-2 (pralmorelin), GHRP-3, GHRP-4, GHRP-5 and GHRP-6.” Everything in this class is prohibited at all times, in and out of competition.

The list is reviewed every year. Competing athletes should check the current version directly rather than rely on a vendor, a review article or me.

Australia

Australia’s Poisons Standard (the SUSMP, June 2026 instrument) names “pralmorelin (GHRP-2)” explicitly in Appendix D, clause 5, alongside hexarelin, ibutamoren and other growth-hormone peptides. Possessing anything on that list without authority is illegal. That goes further than anything FDA has done, and has no US equivalent. I didn’t check whether GHRP-2 is on the ARTG.

Is GHRP-2 the same as HGH?

No. HGH (human growth hormone, the drug ingredient somatropin) is the hormone itself, given by injection. A DailyMed search on 24 September 2026 returns FDA-approved labels for branded somatropin products, including Genotropin, Humatrope, Norditropin, Omnitrope, Serostim and Zomacton.

GHRP-2 is a different molecule meant to make the body release more of its own growth hormone. It has no FDA-approved label at all. Somatropin is a prescription medicine with approved uses; GHRP-2 is not.

What I did not verify

The one human half-life I could verify is about 0.55 hours, roughly 33 minutes, in 10 children with short stature given a single 1 microgram per kilogram intravenous dose Pihoker 1998 - Pihoker C, Kearns GL, French D et al. Pharmacokinetics and pharmacodynamics of growth hormone-releasing peptide-2: a phase I study in children. J Clin Endocrinol Metab. 1998;83(4):1168-72., in the references below. I found no half-life after injection under the skin in adults.

I also didn’t verify when Japan approved GHRP-2, whether it is still marketed there, or whether it is on Australia’s ARTG.

  • GHRP-6: the older peptide in the same GHRP class, separately listed by FDA and separately named by WADA. I haven’t verified a head-to-head comparison with GHRP-2.
  • CJC-1295: a GHRH analogue, one of whose two forms has a published multi-day half-life.
  • Ipamorelin: a GHRP-family relative whose only controlled human trial was stopped for insufficient efficacy.

None of these three is FDA-approved, and all carry the same WADA ban.

Regulatory changes for this compound and others, as they happen: US peptide regulation tracker.

How GHRP-2 compares

Secretagogues (act on the ghrelin receptor). Doses for unapproved compounds are common practice, not trial-established. All growth hormone and muscle peptides →

CompoundMain useEvidenceUsual doseUS status
IpamorelinInvestigated for postoperative ileus, reaching Phase 2 before being discontinued for insufficient efficacy. Marketed to consumers for growth hormone release, an application never approved anywhere.Limited human data100-300 mcg, once nightly on 5 days a week in physician-supervised protocols, up to three times daily on an empty stomach in less structured useResearch use only
MK-677 (Ibutamoren)Developed as an oral, non-injectable alternative to peptide growth hormone secretagogues. Published trials in healthy older adults and obese men found it raised growth hormone and IGF-1 and increased fat-free mass; FDA references a hip-fracture trial that was stopped early. Marketed to consumers as a research chemical for muscle and recovery, a use never approved by any regulator.Limited human data12.5-25 mg, once daily by mouth; the published 2008 trial dosed each morning, while compounding-pharmacy protocols commonly move dosing to before bedResearch use only
GHRP-2Sold to consumers as a growth-hormone-release research chemical for muscle and recovery use, an application never approved anywhere. Historically investigated as a pituitary growth-hormone stimulus and diagnostic agent.Limited human data100-300 mcg, 2 to 3 times daily, on an empty stomach, 5 days a week (5 on, 2 off)Research use only
GHRP-6One of the original growth hormone-releasing peptides, studied since the 1980s as a pituitary GH secretagogue. Marketed to consumers for muscle and recovery goals, an application never approved anywhere.Limited human data100-300 mcg, 2 to 3 times daily, on an empty stomach, spaced at least 3-4 hours apartResearch use only
HexarelinInvestigated since the 1990s as a growth hormone-releasing peptide (GHRP), including for growth-hormone stimulation testing. Sold to consumers as a research chemical for muscle and recovery use, an application with no controlled human trial behind it.Limited human data80-160 mcg, once or twice daily (morning and/or before bed), on an empty stomachResearch use only

Where to buy GHRP-2 for research

Each vendor is checked against my vendor checklist.

  1. 1.Next Level PharmFeatured

    5 mg vial

    • No FDA warning letter found
    • Names its testing lab
    • Batch COAs published
    • Takes card payment

Compare every checked vendor for GHRP-2 →

See all vendors and how they compare →

Common questions

Is GHRP-2 FDA-approved?

No. A DailyMed search on 24 September 2026 returned no drug labels for it, and it is sold as a research chemical labelled not for human use. It is reported to be the only GHRP approved anywhere: Japan lists it as a diagnostic agent for testing growth hormone release, not as a treatment.

Is GHRP-2 safe?

That hasn't been established. FDA lists injectable and nasal GHRP-2 in Category 2 of its compounding policy, for substances with potential significant safety risks. It cites reports of increased insulin requirements, death in critically ill subjects, infection and pancreatitis. The listing is a safety flag, not a full safety review, and it doesn't mean GHRP-2 is safe in other respects.

Is GHRP-2 banned in sport?

Yes. WADA names GHRP-2, by its international name pralmorelin, under section S2.2 of the current Prohibited List. It is banned at all times, in and out of competition. Tested athletes should check the current list directly rather than rely on a vendor or on me.

What is the half-life of GHRP-2?

About 0.55 hours, roughly 33 minutes, in a phase I study of 10 children with short stature given a single 1 microgram per kilogram intravenous dose. That is one small study in children. It doesn't tell you how long GHRP-2 lasts after an injection under the skin in an adult.

Does GHRP-2 build muscle?

No controlled human trial I found shows that it does. GHRP-2 makes the pituitary release growth hormone, and the human studies measured that hormone release, appetite and other hormones, not muscle mass or strength. I couldn't verify any of the muscle claims made in its marketing.

What are the side effects of taking GHRP-2?

FDA's compounding flag cites reports of increased insulin requirements, death in critically ill subjects, infection and pancreatitis, plus a risk of immune reactions from clumping and impurities. Human studies add increased appetite and rises in prolactin, ACTH and cortisol. Other effects listed on vendor and forum sites weren't checked against a primary source, so I don't state them as fact.

Does GHRP-2 make you hungry?

Yes, in the studies that measured it. In 7 lean healthy men, a GHRP-2 infusion under the skin raised the amount eaten at a buffet by 35.9% compared with saline, and in 19 lean and obese adults the increase rose with dose. In 10 children taking it by mouth for a year, 7 reported a significant rise in appetite in the first 6 months. It acts on the same receptor as ghrelin, the body's hunger hormone.

What is the difference between GHRP-2 and HGH?

HGH is growth hormone itself, given by injection, and several branded HGH (somatropin) products have FDA-approved labels. GHRP-2 is a different molecule meant to make the body release more of its own growth hormone. It has no FDA-approved label.

What is the usual GHRP-2 dose?

No clinical trial has set one. Research-community sources describe 100-300 mcg injected under the skin 2-3 times a day on an empty stomach, 5 days on and 2 off, in 8-week cycles with a 4-week break, often mixed with CJC-1295. That is common practice, not a tested dose; the dosing page has the sourcing.

What peptide makes you super hungry?

Among the peptides I cover, growth hormone releasing peptides such as GHRP-2 and GHRP-6 are known for raising appetite, because they act on the receptor for ghrelin, the body's hunger hormone. For GHRP-2 this has been measured: infusions increased how much healthy men ate at a buffet. I don't rank which peptide does it most.

What is the brand name of pralmorelin?

Pralmorelin has no brand on the US market. Outside the US it is sold as GHRP Kaken 100 (Kaken Pharmaceutical).

What is the generic name for GHRP Kaken 100?

The generic name for GHRP Kaken 100 is pralmorelin. GHRP Kaken 100 is Kaken Pharmaceutical's brand, approved for diagnosis of growth hormone deficiency (a one-off stimulation test, not a treatment). It is not approved in the US.

Public cases involving GHRP-2

Official decisions naming GHRP-2, each linked to the announcement. They record what the ruling body found, not whether GHRP-2 works.

Official decisions and statements

  • Steven WrightMLB pitcher (Boston Red Sox)Official statement

    MLB's Commissioner's Office announced an 80-game suspension without pay for Wright after he tested positive for GHRP-2.

    MLB press release, 6 March 2019. Source: Major League Baseball

References (20 sources)

Bibliographic detail is fetched from PubMed, not written by me - so a citation here cannot drift from the paper it names. Study design comes from PubMed's own tags rather than my judgement.

  1. 1.Laferrère B, Abraham C, Russell CD et al. Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men. J Clin Endocrinol Metab. 2005;90(2):611-4.StudyPMID 15699539full text
  2. 2.Laferrère B, Hart AB, Bowers CY. Obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intake. Obesity (Silver Spring). 2006;14(6):1056-63.Randomised trialPMID 16861611full text
  3. 3.Arvat E, di Vito L, Maccagno B et al. Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man. Comparison with the effects of GHRH, TRH and hCRH. Peptides. 1997;18(6):885-91.StudyPMID 9285939
  4. 4.Pihoker C, Kearns GL, French D et al. Pharmacokinetics and pharmacodynamics of growth hormone-releasing peptide-2: a phase I study in children. J Clin Endocrinol Metab. 1998;83(4):1168-72.Clinical trialPMID 9543135
  5. 5.Chihara K, Shimatsu A, Hizuka N et al. A simple diagnostic test using GH-releasing peptide-2 in adult GH deficiency. Eur J Endocrinol. 2007;157(1):19-27.Clinical trialPMID 17609397
  6. 6.Asakura Y, Toyota Y, Muroya K et al. Growth hormone response to GH-releasing peptide-2 in children. J Pediatr Endocrinol Metab. 2010;23(5):473-80.StudyPMID 20662346
  7. 7.Okano M, Nishitani Y, Sato M et al. Influence of intravenous administration of growth hormone releasing peptide-2 (GHRP-2) on detection of growth hormone doping: growth hormone isoform profiles in Japanese male subjects. Drug Test Anal. 2010;2(11-12):548-56.StudyPMID 21249726
  8. 8.Mericq V, Cassorla F, Salazar T et al. Effects of eight months treatment with graded doses of a growth hormone (GH)-releasing peptide in GH-deficient children. J Clin Endocrinol Metab. 1998;83(7):2355-60.Clinical trialPMID 9661608
  9. 9.Mericq V, Cassorla F, Bowers CY et al. Changes in appetite and body weight in response to long-term oral administration of the ghrelin agonist GHRP-2 in growth hormone deficient children. J Pediatr Endocrinol Metab. 2003;16(7):981-5.Clinical trialPMID 14513874
  10. 10.Van den Berghe G, Wouters P, Weekers F et al. Reactivation of pituitary hormone release and metabolic improvement by infusion of growth hormone-releasing peptide and thyrotropin-releasing hormone in patients with protracted critical illness. J Clin Endocrinol Metab. 1999;84(4):1311-23.Randomised trialPMID 10199772
  11. 11.Phung LT, Inoue H, Nou V et al. The effects of growth hormone-releasing peptide-2 (GHRP-2) on the release of growth hormone and growth performance in swine. Domest Anim Endocrinol. 2000;18(3):279-91.StudyPMID 10793268
  12. 12.Popławska M, Błażewicz A. Identification of a novel growth hormone releasing peptide (a glycine analogue of GHRP-2) in a seized injection vial. Drug Test Anal. 2019;11(1):162-167.StudyPMID 30051972
  13. 13.Dominikowski A, Rękoś Z, Olejarz M et al. The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration. Front Endocrinol (Lausanne). 2026;17:1822475.ReviewPMID 42395176full text
  14. 14.FDA - Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks. Category 2 table lists "Growth hormone releasing peptide-2 (GHRP-2) (for injectable and nasal routes of administration)", 503B, added 29 September 2023.- US Food and Drug Administrationregulatory
  15. 15.DailyMed search for "GHRP-2" - zero drug package labels found, checked 2026-09-24.- US National Library of Medicinedatabase
  16. 16.DailyMed search for "somatropin" - 59 results including FDA-approved labels for branded somatropin (HGH) products such as Genotropin, Humatrope, Norditropin, Omnitrope, Serostim and Zomacton, checked 2026-09-24.- US National Library of Medicinedatabase
  17. 17.WADA 2026 Prohibited List, section S2.2 (Peptide Hormones and their Releasing Factors) - names "GHRP-1, GHRP-2 (pralmorelin)" among GH-releasing peptides, prohibited at all times (national anti-doping agency mirror, PDF; also verified directly on wada-ama.org).- Jamaica Anti-Doping Commission (mirroring the World Anti-Doping Agency 2026 Prohibited List)regulatory
  18. 18.Therapeutic Goods (Poisons Standard - June 2026) Instrument 2026, the current Poisons Standard (SUSMP). Appendix D, clause 5 names "pralmorelin (GHRP-2)" explicitly among growth hormone releasing peptides for which possession without authority is illegal.- Federal Register of Legislation, Australian Governmentstatute
  19. 19.KEGG DRUG D02040 - pralmorelin hydrochloride (JAN), brand GHRP: a Japanese product classed as a diagnostic reagent for endocrine function, listed under new drug approvals in Japan.- Kanehisa Laboratories, Kyoto Universitydatabase
  20. 20.GHRP KAKEN 100 Injection (pralmorelin hydrochloride) - Japanese package insert, revised July 2025- KEGG MEDICUS (Japanese package insert, JAPIC)label