Prostamax (KEDP): What the Research Shows, Dosage and Legal Status

Prostamax is one of several Khavinson bioregulator peptides covered on this site, alongside Epitalon and Pinealon. As with those, the research is real but thin and comes from one research lineage. For Prostamax, none of it is in prostate tissue.

What is Prostamax?

Prostamax is a short synthetic peptide of four amino acids, Lys-Glu-Asp-Pro (KEDP). It comes from Vladimir Khavinson’s organ-specific bioregulator programme, which also produced Epitalon and Pinealon. It is marketed as a prostate peptide, designed as a chemically defined successor to the older, less-defined prostate-tissue extracts used in that research tradition.

Prostamax structure

Molecular formula

C₂₀H₃₃N₅O₉

Molecular weight

487.5 g/mol

Length

4 amino acids

Sequence

KEDP

PubChem CID

9848296

Identity checked against Georgian Medical News (2012), via PubMed.

How Prostamax works

Researchers propose that Prostamax acts on chromatin, the packaging of DNA, in aging cells rather than through a conventional receptor. Two studies in cultured blood cells (lymphocytes) from older adults, aged 75-86 in one study, found that it loosened chromatin that had become tightly packed with age Meskhi 2004 - Meskhi T, Khachidze D, Barbakadze Sh et al. [The influence of the peptide bioregulator prostamax on heterochromatin of human lymphocytes in situ]. Biofizika. 2004;49(6):1091-3., in the references below Dzhokhadze 2012 - Dzhokhadze TA, Buadze TZh, Gaĭozishvili MN et al. [Deheterochromatinization of the chromatin in old age induced by oligopeptide bioregulator (Lys-Glu-Asp-Pro)]. Georgian Med News. 2012., in the references below. The researchers read this as switching back on genes that age had silenced.

A third study set out to test Prostamax with copper and cadmium ions on lymphocytes from older people. Its abstract reports results only for the metal ions, not for Prostamax Kiladze 2009 - Kiladze M, Gorgoshidze M, Monaselidze J et al. Microcalorimetric study of human blood lymphocytes culture at presence of copper, cadmium and prostamax. Georgian Med News. 2009., in the references below.

Prostamax benefits: what the research shows

I found no published human trial of synthetic Prostamax measuring any prostate outcome: symptom score, flow rate, gland size or anything else. The evidence is the blood-cell chromatin studies above, plus one rat study.

That rat study tested Prostamax alongside three related bioregulators (cardiogen, bronchogen and pancragen) on heart, lung, prostate and pancreas tissue from young and old rats, kept alive in culture. Each peptide, at 0.05 ng/ml, stimulated its matched tissue compared with untreated samples Zakutskiĭ 2006 - Zakutskiĭ AN, Chalisova NI, Ryzhak GA et al. [The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats]. Adv Gerontol. 2006;19:93-6., in the references below.

Nothing I could verify supports marketing claims about prostate symptoms or urinary flow for this compound.

Prostamax dosage

No published trial or regulator has set a dose. Research-chemical dosing guides describe 0.75 to 2 mg injected under the skin once a day, from a 20 mg vial. That is common practice, not a tested dose. The two sources I checked disagree on course length: 10-20 days in one, 8 weeks with a mid-course dose increase in the other.

Common protocol

What is commonly used, not a dose established in trials. No regulator has set a dose for Prostamax. Sources differ, so the ranges below span them.

Dose per administration

750-2000 mcg

How often

once daily, subcutaneous, often started lower and increased after 1-4 weeks

Route

Subcutaneous injection

Cycle length

1.4-8 weeks

Common vial size

20 mg

Sources disagree substantially on how long a course runs: one describes a 0.75 mg starting dose for the first 10 days rising to a 2 mg maintenance dose for a total course of up to 8 weeks; the other describes a much shorter 10-20 day 'bioregulator convention' course at roughly 1-2 mg. Neither states a break length between courses. Prostamax (the synthetic tetrapeptide covered here) is a different product from Prostatilen, an older bovine prostate extract with its own, separate clinical literature; one of these sources explicitly warns the two are sometimes conflated in vendor marketing.

Plan a cycle in the protocol builder or work out injection volume in the dosage calculator.

The common Prostamax dose is 750-2000 mcg, once daily, subcutaneous, often started lower and increased after 1-4 weeks. From a 20 mg vial mixed with 2 mL of bacteriostatic water, 1.5 mg is 15 units (0.15 mL) on a U-100 insulin syringe.

Prostamax 20 mg vial: units per dose

Full 20 mg vial page: mixing, doses per vial, how long it lasts →

Water added	Concentration	1 unit =	750 mcg	1.5 mg	2 mg
1 mL	20 mg/mL	200 mcg	4 units	7.5 units	10 units
2 mL	10 mg/mL	100 mcg	7.5 units	15 units	20 units
3 mL	6.67 mg/mL	66.67 mcg	11.5 units	22.5 units	30 units

All Prostamax vial sizes: 20 mg

Units are on a standard U-100 insulin syringe (100 units = 1 mL), rounded to the nearest half unit - half-unit marks are on 0.3 mL syringes. Water volumes are examples: more water means more units per dose, not more doses per vial. For any other vial or dose, use the dosage calculator.

How many 20 mg vials a cycle takes

Scenario	Dose	Doses a week	Weeks	Total	20 mg vials
Low end of the common protocol	750 mcg	7	1.4	7.5 mg	1
High end of the common protocol	2 mg	7	8	112 mg	6

Whole vials, rounded up. Plan a cycle with your own numbers in the protocol builder. Keep mixed vials cold and use them within the window in how long reconstituted peptides last; where to inject: subcutaneous injection sites.

Prostamax side effects

No human safety study of synthetic Prostamax has been published, so no side-effect rate, common or rare, is known. The chromatin studies measured a lab endpoint in blood cells and were not designed to look for adverse events.

It is sold through unregulated research-chemical channels, so no regulator checks that a vial matches its label. Because it is injected, see peptide injection-site reactions for what to watch for at the injection site; that is a general risk of injecting, not specific to Prostamax.

Is Prostamax legal?

Prostamax is not approved by the FDA or any other regulator for any use. It is sold through research-chemical channels, not a regulated pharmaceutical supply chain.

Regulatory changes for this compound and others, as they happen: US peptide regulation tracker.

Related reading

• Bioregulator peptides: the Khavinson family, explained
• Epitalon - the longevity-focused peptide from the same research programme
• Pinealon - a cognition-focused peptide from the same programme
• Are peptides safe?

How Prostamax compares

Bioregulators. Doses for unapproved compounds are common practice, not trial-established. All bioregulators peptides →

Compound	Main use	Evidence	Usual dose	US status
Prostamax	Marketed as a prostate-tissue bioregulator for age-related prostate change, from the Khavinson organ-specific peptide programme.	Animal / lab only	750-2000 mcg, once daily, subcutaneous, often started lower and increased after 1-4 weeks	Research use only
Epitalon	Sold for longevity and anti-aging on the basis of telomere research.	Animal / lab only	5-10 mg, once nightly, every night, for the length of the cycle	Research use only
Pinealon	Sold for cognition, focus and healthy aging.	Limited human data	1-2 mg, once daily, morning preferred; some protocols run 5 days a week rather than every day	Research use only
Cartalax	Marketed for cartilage and joint support, sold as a "cartilage bioregulator" for age-related joint wear.	Animal / lab only	200 mcg, once daily	Research use only
Testagen	Marketed for testosterone and reproductive-system support, sold as a "testes bioregulator."	Animal / lab only	10-20 mg, once daily by mouth	Research use only
Vilon	Marketed as a thymus and immune-system bioregulator, sold for immune support and healthy ageing.	Animal / lab only	10-20 mg, once daily by mouth	Research use only
Vesugen	Marketed as a vascular-tissue bioregulator for cardiovascular and blood-vessel aging; more recent papers from the same research group also study it as a candidate for age-related cognitive decline.	Limited human data	500-5000 mcg, once daily, subcutaneous, commonly started low and titrated upward over the first 1-3 weeks	Research use only
Cardiogen	Marketed as a heart-tissue bioregulator for cardiovascular aging, from the Khavinson organ-specific peptide programme.	Animal / lab only	200-2000 mcg, once daily, subcutaneous, most commonly cited around 1 mg/day	Research use only

Where to buy Prostamax for research

Each vendor is checked against my vendor checklist.

1. 1.BioEdge Research Labs

   20 mg vial

   • No FDA warning letter found
   • Names its testing lab
   • Batch COAs published

   $59.00as of 3 October 2026

   View product →My BioEdge Research Labs review

See all vendors and how they compare →

Common questions

What is the usual Prostamax dose?

No trial or regulator has set one. Two research-chemical dosing guides I checked describe 0.75-2 mg injected under the skin once a day, from a 20 mg vial. They disagree on course length: 10-20 days in one, 8 weeks with a mid-course dose increase in the other. See the dosage section below.

What are the side effects of Prostamax?

No human safety study of synthetic Prostamax has been published, so there is no verified side-effect rate. See the side effects section on this page for what is and isn't known.

Is Prostamax the same thing as Prostatilen?

No. Prostatilen is an older extract of cow prostate tissue with its own, larger clinical literature. Prostamax is the later, chemically defined synthetic peptide (Lys-Glu-Asp-Pro). Vendors sometimes blur the two, but Prostatilen's evidence does not transfer to Prostamax.

References (4 sources)

Show

Bibliographic detail is fetched from PubMed, not written by me - so a citation here cannot drift from the paper it names. Study design comes from PubMed's own tags rather than my judgement.

1. 1.Kiladze M, Gorgoshidze M, Monaselidze J et al. Microcalorimetric study of human blood lymphocytes culture at presence of copper, cadmium and prostamax. Georgian Med News. 2009.StudyPMID 19359734
2. 2.Meskhi T, Khachidze D, Barbakadze Sh et al. [The influence of the peptide bioregulator prostamax on heterochromatin of human lymphocytes in situ]. Biofizika. 2004;49(6):1091-3.StudyPMID 15612551
3. 3.Dzhokhadze TA, Buadze TZh, Gaĭozishvili MN et al. [Deheterochromatinization of the chromatin in old age induced by oligopeptide bioregulator (Lys-Glu-Asp-Pro)]. Georgian Med News. 2012.StudyPMID 23221144
4. 4.Zakutskiĭ AN, Chalisova NI, Ryzhak GA et al. [The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats]. Adv Gerontol. 2006;19:93-6.StudyPMID 17152728

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