Pinealon: Twenty-Two Papers and No Clinical Trials
Pinealon is a three-amino-acid peptide with a mechanism hypothesis and essentially no human evidence. This is the shortest page on the site, and that is the finding.
Start here
Plain English
Pinealon is a synthetic tripeptide from the Russian peptide-bioregulator programme, sold for cognition and aging. PubMed holds 22 records for it, none of them clinical trials. There is a mechanism hypothesis and almost nothing else.
- 22 papers in total, and no clinical or randomised trials at all.
- The work that exists is laboratory work on gene and protein expression.
- Not approved for human use; sold as a research chemical.
This is the shortest compound page on the site. That is not neglect — it is the most accurate summary we can give you.
What it is
Pinealon is a synthetic tripeptide made of glutamic acid, aspartic acid and arginine, which is why the literature usually calls it EDR peptide. It comes from the same Russian peptide-bioregulator programme as Epitalon and shares that programme’s characteristics Khavinson 2002 - Khavinson VKh. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144. (opens PubMed in a new tab).
It is sold for cognition, focus and healthy aging.
What exists to read
The substantive work is laboratory research proposing mechanisms by which the peptide might regulate gene expression and protein synthesis Khavinson 2020 - Khavinson V, Linkova N, Kozhevnikova E et al. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease. Molecules. 2020;26(1). (opens PubMed in a new tab).
Where this leaves you
We cover compounds people are actually buying, and Pinealon is one of them. But it would be dishonest to build a long page here — to describe mechanisms at length, walk through speculative benefits, and let the volume of words imply a volume of evidence that does not exist.
If you want the same argument set out properly, the Epitalon and Semax and Selank pages cover this research tradition and what can and cannot be concluded from it. Pinealon sits at the thinnest end of it.
Status
US legal status - Research use only · not for human use
Sold for laboratory research use only. Not approved by the FDA for human use, and cannot be lawfully marketed as a supplement or a medicine. Products sold this way are not made to pharmaceutical quality standards, and their contents are not verified by anyone.
Not approved for human use, sold as a research chemical, contents unverified by anyone.
References
Bibliographic detail is fetched from PubMed, not written by us - so a citation here cannot drift from the paper it names. Study design comes from PubMed's own tags rather than our judgement.
- 1.Khavinson V, Linkova N, Kozhevnikova E et al. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease. Molecules. 2020;26(1).ReviewPMID 33396470full text
- 2.Khavinson VKh. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144.ReviewPMID 12374906